My CRS score with wife is around 454, should I put my application in the pool? Also is WES needed for Express Entry?

Based on recent trends, your chance is limited. So your best bet will be provincial nomination or French. However based on the changes we are hearing about that will be implemented next year, you may but I can’t say that with certainty.

With upcoming occupations in demand dependent draws, crs score will not matter but ur education, language and occupation will decide if you will b invited or not, in my humble opinion.