If your NOC is in demand for a provincial stream (in this example, Ontario's OINP with NOC 0601), but including your spouse on your Express Entry profile pushes your CRS score too high for that stream's typical range, you don't necessarily have to remove your spouse from the application entirely.
Suggested approach: Instead of marking your spouse as "not accompanying" (which can trigger extra scrutiny and requires a credible reason), try removing or not claiming your spouse's education credential assessment (ECA) points and/or their IELTS/language test points from the profile. This lowers your combined CRS score without changing your spouse's accompanying status, so you avoid the paperwork and risk of justifying a non-accompanying spouse.
This is a manual CRS calculation exercise: recalculate your score with and without your spouse's education and language points to see which combination lands you in the target PNP range, then decide which points to omit from the profile accordingly.